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Rituximab therapy for patients with Langerhans cell histiocytosis-associated neurologic dysfunction
Olive Eckstein1, Casey L McAtee1, Jay Greenberg2
1a Texas Children's Cancer Center , Houston , Texas , USA.
Objective:
Since patients with langerhans cell histiocytosis and neurologic dysfunction (LCH-ND) often have incomplete treatment responses we sought a new treatment regimen. Because of clinical benefit from rituximab in multiple sclerosis patients with neurodegeneration, we evaluated its use in patients with LCH-ND.
Participants:
Eight LCH-ND patients who had failed prior therapies.
Methods:
Charts of the 8 patients treated with rituximab were reviewed. Signs/symptoms and MRI responses were assessed.
Results:
Seven of eight patients experienced some clinical improvement: gait abnormalities and tremors in four children, proprioceptive deficits in 2, and dysarthria/dysphagia in 2. Five of eight patients demonstrated improvement in intellectual/behavioral/psychological symptoms.
Conclusion:
These findings suggest that prospective studies are warranted to define safety and efficacy of rituximab for patients with LCH-ND.
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