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Updated: Jan 31, 2026

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains
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Spinal Shox2 interneuron interconnectivity related to function and development.

Ngoc T Ha1, Kimberly J Dougherty1

  • 1Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, United States.

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|January 1, 2019
PubMed
Summary
This summary is machine-generated.

Spinal cord interneurons called Shox2 connect via electrical synapses, aiding synchronized network activity crucial for hindlimb locomotion in developing mice.

Keywords:
gap junctionslocomotionmouseneurosciencerhythm generationspinal cordsynaptic connectivity

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Area of Science:

  • Neuroscience
  • Spinal Cord Research
  • Developmental Biology

Background:

  • Locomotion is controlled by spinal cord neuronal networks.
  • The precise mechanisms of spinal rhythm generation remain unclear.
  • Excitatory interneuron activity and connectivity are key factors.

Purpose of the Study:

  • To investigate the interconnectivity within the Shox2 interneuron population.
  • To determine the role of Shox2 interneurons in locomotor rhythm generation.
  • To explore the nature and developmental changes of Shox2 interneuron connections.

Main Methods:

  • Paired recordings in isolated spinal cords and slices from transgenic mice.
  • Analysis of both chemical and electrical synaptic transmission.
  • Assessment of connection properties in neonatal and ~3-week-old mice.

Main Results:

  • Shox2 interneurons exhibit sparse unidirectional chemical synapses.
  • Prominent bidirectional electrical synapses connect distinct Shox2 interneuron subsets.
  • Electrical coupling is stronger and more frequent in neonatal mice, declining with age.
  • Functionally related Shox2 interneurons show preferential electrical coupling.

Conclusions:

  • Gap junctional coupling synchronizes Shox2 interneurons.
  • This synchronization is likely important for locomotor rhythmicity during development.
  • Shox2 interneurons play a significant role in the generation of hindlimb locomotion.