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Updated: Jan 31, 2026

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
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Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

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Baseline Troponin T level in stroke and its association with stress cardiomyopathy

Kai Liesirova1, Eugenio Abela1, Thomas Pilgrim2

  • 1Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Plos One
|January 1, 2019
PubMed

Insights

Elevated high-sensitive Troponin T (hsTnT) in acute ischemic stroke is linked to stroke severity and kidney function, not stroke size. Differentiating myocardial infarction from neurogenic stunned myocardium requires further cardiac investigations.

Area of Science:

  • Cardiology
  • Neurology
  • Biomarkers

Background:

  • Elevated high-sensitive Troponin T (hsTnT) in acute ischemic stroke (AIS) presents a diagnostic challenge, with differential diagnoses including myocardial infarction (MI) and neurogenic stunned myocardium (NSM).
  • Understanding factors associated with hsTnT elevation is crucial for accurate diagnosis and patient management in AIS.

Purpose of the Study:

  • To identify factors associated with baseline hsTnT levels in patients with acute ischemic stroke.
  • To explore predictors of myocardial infarction (MI) and neurogenic stunned myocardium (NSM) in the context of elevated hsTnT in AIS.

Main Methods:

  • Retrospective analysis of 204 consecutive patients with AIS from the Bern Stroke Database.
  • Review of patient histories, cardiac examinations, and brain imaging (diffusion/perfusion weighted MRI) including lesion volumetry.
  • Linear regression analysis to identify predictors of hsTnT levels and MI.

Main Results:

  • Elevated hsTnT was observed in 28.4% of patients.
  • hsTnT elevation correlated with creatinine levels, baseline NIHSS score, ST segment depression, and inverted T waves on ECG.
  • Stroke infarct location and size were not associated with hsTnT elevation. MI was diagnosed in 7 of 30 patients who underwent coronary angiography.

Conclusions:

  • Baseline hsTnT elevation in AIS is associated with stroke severity and cardiac abnormalities but not stroke size.
  • Current factors are insufficient to differentiate between MI and NSM, necessitating further cardiac investigations like coronary angiography or cardiac MRI.
Abstract

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