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Related Experiment Video

Updated: Jan 31, 2026

Endothelin-1 Induced Middle Cerebral Artery Occlusion Model for Ischemic Stroke with Laser Doppler Flowmetry Guidance in Rat

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Endothelin impacts on olfactory processing in rats.

Bertrand Bryche¹, Mikaël Le Bourhis¹, Patrice Congar¹

¹NBO, INRA, Université Paris-Saclay, 78350, Jouy-en-Josas, France.

Behavioural Brain Research

|January 1, 2019

Summary

This summary is machine-generated.

Endothelin-1 (ET-1) affects olfactory responses by uncoupling sustentacular cell gap junctions. This modulation impacts odorant detection and processing in the olfactory epithelium, influencing behavioral outcomes.

Keywords:

Behavioral tests Calcium signals Carbenoxolone Electro-olfactogram Endothelin Olfactory mucosa

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Published on: June 5, 2017

Area of Science:

Neuroscience
Olfactory System Biology
Cellular Physiology

Background:

Sustentacular cells in the olfactory epithelium maintain mucosal integrity.
Endothelin-1 (ET-1) is known to uncouple gap junctions in vitro.
The role of gap junctions in olfactory transduction is debated.

Purpose of the Study:

To investigate the impact of endothelin-1 (ET-1) on olfactory responses.
To determine if ET-1, naturally present in the olfactory mucosa, affects odorant detection.
To explore the role of gap junction uncoupling in olfactory processing.

Main Methods:

Calcium imaging of olfactory mucosa explants to assess gap junction uncoupling by ET-1.
Electro-olfactogram (EOG) recordings to measure olfactory epithelium responses to odorants.
Behavioral orientation tests in rat pups using maternal odor recognition after ET-1 or carbenoxolone treatment.

Main Results:

ET-1 confirmed to uncouple gap junctions in intact olfactory mucosa.
ET-1 and carbenoxolone slowed the repolarizing phase of olfactory epithelium responses to odorants.
ET-1 treatment decreased rat pup performance in maternal odor recognition, while carbenoxolone did not.

Conclusions:

Endothelin-1 (ET-1) modulates olfactory responses, partly via gap junction uncoupling.
Gap junction uncoupling by ET-1 influences olfactory processing and odorant detection.
ET-1 plays a role in the functional integrity of the olfactory system.