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Updated: Jan 31, 2026

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
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Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Published on: April 1, 2015

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Sex difference in fibrin clot lysability: Association with coronary plaque composition

Ramshanker Ramanathan1, Jørgen B Gram2, Johannes J Sidelmann2

  • 1Department of Cardiology, Hospital of South West Denmark, Esbjerg, and Department of Regional Health Research, University of Southern Denmark, Denmark; Department of Clinical Biochemistry, Hospital of South West Denmark, Esbjerg, and Unit for Thrombosis Research, Department of Regional Health Research, University of Southern Denmark, Denmark.

Thrombosis Research
|January 1, 2019
PubMed

Insights

Women with coronary plaques show reduced fibrin clot lysability, a key factor in cardiovascular disease (CVD). This suggests a sex-specific link between atherosclerosis and clot breakdown, impacting CVD development.

Area of Science:

  • Cardiovascular Science
  • Hematology
  • Medical Imaging

Background:

  • Fibrin clot lysability is linked to cardiovascular disease (CVD) development.
  • Understanding sex differences in fibrin clot lysability and its association with coronary atherosclerosis is crucial for CVD risk assessment.

Purpose of the Study:

  • To evaluate sex differences in fibrin clot lysability.
  • To assess the association between fibrin clot lysability and coronary plaque composition determined by computed tomography angiography (CTA).

Main Methods:

  • 138 middle-aged individuals without known CVD were recruited.
  • Coronary CTA was used to assess plaque volumes (calcified, non-calcified, low-density non-calcified, total).
  • Fibrin structure properties and plasma fibrinogen levels were analyzed.

Main Results:

  • Women with coronary plaques had significantly lower fibrin clot lysability compared to women without plaques (P=0.02).
  • Fibrinogen levels correlated with coronary plaque features in women with plaques (r=0.42-0.57, P<0.01).
  • While men had more plaques, overall plaque features were comparable; women showed a trend towards lower lysability compared to men.

Conclusions:

  • Asymptomatic women with coronary plaques exhibit reduced fibrin clot lysability.
  • This finding suggests a sex-dependent association between coronary atherosclerosis and impaired fibrin clot breakdown.
  • The results highlight potential sex-specific mechanisms in CVD pathogenesis.
Abstract

Keywords:
Cardiovascular diseaseCoronary plaque compositionFibrin clot lysabilitySex-difference

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