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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Ribosomes01:27

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Ribosomes translate genetic information encoded by messenger RNA (mRNA) into proteins. Both prokaryotic and eukaryotic cells have ribosomes. Cells that synthesize large quantities of protein—such as secretory cells in the human pancreas—can contain millions of ribosomes.
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Ribosomes translate genetic information encoded by messenger RNA (mRNA) into proteins. Both prokaryotic and eukaryotic cells have ribosomes. Cells that synthesize large quantities of protein—such as secretory cells in the human pancreas—can contain millions of ribosomes.
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Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
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Cis-regulatory Sequences02:02

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Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
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Using SecM Arrest Sequence as a Tool to Isolate Ribosome Bound Polypeptides
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Identifying sequence features that drive ribosomal association for lncRNA.

Chao Zeng1,2, Michiaki Hamada3,4,5,6,7

  • 1Faculty of Science and Engineering, Waseda University, 55N-06-10, 3-4-1 Okubo Shinjuku-ku, Tokyo, 169-8555, Japan. zeng.chao@aist.go.jp.

BMC Genomics
|January 2, 2019
PubMed
Summary

Researchers identified key sequence features distinguishing ribosome-associated long noncoding RNAs (lncRNAs) from ribosome-free ones. This discovery offers insights into lncRNA function and ribosomal association mechanisms.

Keywords:
Feature selectionRibosome-associatedSequence featurelncRNA

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Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • Thousands of long noncoding RNAs (lncRNAs) are found to associate with ribosomes in mammals.
  • The biological functions and mechanisms of ribosome-associated lncRNAs remain largely unknown.

Purpose of the Study:

  • To investigate sequence features that determine ribosomal association in long noncoding RNAs (lncRNAs).
  • To differentiate between ribosome-associated and ribosome-free lncRNAs based on sequence characteristics.

Main Methods:

  • Extraction of ninety-nine sequence features related to RNA splicing, open reading frames, k-mer frequency, modification, secondary structure, and repeat elements.
  • Application of an [Formula: see text]-regularized logistic regression model for feature screening.

Main Results:

  • Identification of fifteen critical sequence features for human lncRNA ribosomal association.
  • Identification of nine critical sequence features for mouse lncRNA ribosomal association.

Conclusions:

  • This study is the first to characterize ribosome-associated and ribosome-free lncRNAs using sequence features.
  • Identified sequence features may elucidate the mechanism of ribosomal association and aid in lncRNA functional analysis.