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Comparison of Risk Factors Related to Intraventricular Hemorrhage between Preterm Infants Born After Normal and in

Mamak Shariat1, Parisa Mohagheghi2, Zahra Farahani1

  • 1Maternal & Child Health Specialist, Maternal-Fetal & Neonatal Research Center, Tehran University of Medical Sciences, Imam Khomeini Hospital,Tehran, Iran.

Iranian Journal of Child Neurology
|January 2, 2019
PubMed

Insights

Infants conceived via in vitro fertilization (IVF) have a higher incidence of intraventricular hemorrhage (IVH), particularly severe grades. Multi-gestational pregnancy was a significant risk factor for IVH in non-IVF conceived infants.

Area of Science:

  • Neonatal Medicine
  • Reproductive Medicine
  • Perinatal Research

Background:

  • Intraventricular hemorrhage (IVH) is a significant concern in preterm infants.
  • Understanding risk factors for IVH is crucial for improving neonatal outcomes.
  • In vitro fertilization (IVF) is increasingly used, necessitating research into its effects on neonatal health.

Purpose of the Study:

  • To compare the incidence and risk factors of intraventricular hemorrhage (IVH) between preterm infants conceived via IVF and those conceived naturally.
  • To identify specific risk factors associated with IVH in these two groups.

Main Methods:

  • A historical cohort study involving 155 preterm newborns in four Iranian hospitals (2013-2014).
  • Infants were divided into case (IVF conception) and control (natural conception) groups.
  • Demographic data, IVH incidence, grades, and potential risk factors were analyzed and compared.

Main Results:

  • The incidence of IVH, especially grades II and III, was significantly higher in the IVF group (P=0.003).
  • No significant correlation was found between gestational age, birth weight, or number of gestations and IVH in the IVF group.
  • Multi-gestational pregnancy emerged as a significant risk factor for IVH in the control (natural conception) group (P=0.0001).

Conclusions:

  • IVF conception is associated with a significantly higher incidence of intraventricular hemorrhage in preterm infants.
  • IVF may act as an independent risk factor for high-grade IVH.
  • Multi-gestational pregnancy is a key risk factor for IVH in naturally conceived preterm infants.
Abstract

Keywords:
In vitro fertilizationIntraventricular hemorrhageNatural conception

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