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Related Experiment Videos

Fluid dynamics during bronchoalveolar lavage.

C A Kelly1, J D Fenwick, P A Corris

  • 1Department of Medicine, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom.

The American Review of Respiratory Disease
|July 1, 1988
PubMed
Summary
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Bronchoalveolar lavage (BAL) causes significant fluid exchange between the lungs and circulation. Studies show about 44% of the BAL fluid is gained by the lung segment, originating from the interstitium and pulmonary circulation.

Area of Science:

  • Pulmonary Medicine
  • Respiratory Physiology

Background:

  • Bronchoalveolar lavage (BAL) is a common diagnostic procedure.
  • The extent of fluid exchange during BAL is not fully quantified.

Purpose of the Study:

  • To quantify fluid exchange between lung segments and the interstitium or pulmonary circulation during standardized BAL.
  • To determine the origin of fluid gained by the lung segment during BAL.

Main Methods:

  • Used technetium colloid and methylene blue to measure fluid dilution during BAL.
  • Incorporated tritiated water to assess water efflux from the lung segment.
  • Assayed urea concentrations in plasma and aspirate, and tritium levels in plasma and lavage aspirate to determine fluid origins.

Main Results:

Related Experiment Videos

  • Fluid dilution during BAL was approximately 25%, indicating a total dilution volume of about 225 ml.
  • Tritiated water dilution suggested approximately 55 ml of water effluxed from the lung segment.
  • Calculated a total fluid gain of approximately 100 ml (44% of dilution volume) by the lung segment.
  • Determined that fluid normally resident in the lung segment contributed at most about 2% to the aspirated volume.
  • Established that a median of 39% of aspirated fluid originated from the circulation or interstitium.

Conclusions:

  • Bronchoalveolar lavage involves substantial fluid exchange with the lung interstitium and pulmonary circulation.
  • A significant portion of fluid gained by the lung segment during BAL originates from systemic circulation and surrounding interstitium.
  • The study quantifies fluid dynamics during BAL, providing insights into respiratory physiology.