The CRISPR revolution in fungal biology and biotechnology, and beyond

Crop cultivation has a long history in human civilization, with records showing the cultivation of cereal plants beginning at around 8000 BC. This early plant breeding was developed primarily to provide a steady supply of food.

Surfaces of revolution are formed when a two-dimensional curve is rotated around an axis, producing a three-dimensional shape. This concept is used in engineering tasks like determining the surface area of a rocket nozzle, where precise calculations are critical for applying uniform heat-resistant coatings. When a curve is revolved about the x-axis, it sweeps out a continuous surface whose area must be calculated accurately to estimate material requirements.Approximating with Conical BandsTo...

Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...

Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...

The paraboloid of revolution is an axially symmetric surface generated by rotating a parabola around its axis. This shape has several applications in mechanical engineering due to its advantageous structural properties, such as strength against stress concentration points and rotational symmetry.
The centroid for the paraboloid of revolution is the point where all the mass of the paraboloid is concentrated. This centroid is important for engineering applications, as it determines how forces are...

Volumes of irregularly shaped objects can be systematically determined using the concept of solids of revolution. This approach begins with a region defined by a curve in a two-dimensional plane. When this region is rotated about a fixed line, known as the axis of revolution, it generates a three-dimensional object with rotational symmetry. Such objects frequently arise in mathematical modeling, physics, and engineering applications.When the region being rotated lies directly against the axis...