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Early experience with Millipede IRIS transcatheter mitral annuloplasty
Jason H Rogers1, Walter D Boyd2, Thomas W Smith1
1Division of Cardiovascular Medicine, University of California, Davis Medical Center, Sacramento, CA, USA.
Annals of Cardiothoracic Surgery
|January 2, 2019
Summary
The IRIS mitral annuloplasty ring effectively treats severe mitral regurgitation by reducing annular size and improving leaflet coaptation. Early results show significant reduction in mitral regurgitation and improved patient symptoms.
Area of Science:
- Cardiovascular Surgery
- Interventional Cardiology
- Medical Devices
Background:
- The IRIS mitral annuloplasty ring is a novel device designed for transcatheter delivery to address mitral regurgitation (MR).
- It aims to replicate surgical annuloplasty by reducing mitral annular dimensions and enhancing leaflet coaptation.
- This study reports the initial clinical experience with the IRIS system in patients with severe MR and annular dilation.
Discussion:
- The IRIS system was implanted in seven symptomatic patients with severe MR (3-4+).
- Both surgical and transcatheter (transfemoral, transseptal) delivery methods were evaluated.
- No procedural deaths or myocardial infarctions occurred.
Key Insights:
- The IRIS ring significantly reduced the mitral septal-lateral diameter by 31.8% at 30 days.
- All patients experienced a reduction in MR from severe (3-4+) to mild (0-1+).
- Left ventricular diastolic volumes decreased by 36.8%, with improvements in NYHA functional class.
Outlook:
- The early positive findings support ongoing clinical trials to further assess the IRIS ring's safety and efficacy.
- This transcatheter approach offers a potential alternative for patients with severe mitral regurgitation.
- Further research will determine the long-term outcomes and broader applicability of the IRIS system.
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