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Mitochondrial function and abnormalities implicated in the pathogenesis of ASD.

Frank J Castora1

  • 1Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA, USA; Department of Neurology, Eastern Virginia Medical School, Norfolk, VA, USA.

Progress in Neuro-Psychopharmacology & Biological Psychiatry
|January 2, 2019
PubMed
Summary
This summary is machine-generated.

Mitochondrial dysfunction is increasingly linked to autism spectrum disorders (ASD). This review explores the latest evidence on mitochondrial abnormalities in ASD pathogenesis and potential therapeutic strategies.

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Area of Science:

  • Cell Biology
  • Neuroscience
  • Genetics

Background:

  • Mitochondria are vital for cellular energy (ATP) production and numerous metabolic processes.
  • Mitochondrial dysfunction is implicated in various disorders, including neurodegenerative and neurodevelopmental conditions.
  • Growing evidence links mitochondrial dysfunction and abnormalities in mitochondrial DNA (mtDNA) to the pathogenesis of Autism Spectrum Disorders (ASD).

Purpose of the Study:

  • To review the latest evidence connecting mitochondrial dysfunction and mtDNA abnormalities to ASD development.
  • To summarize recent therapeutic approaches aimed at improving mitochondrial function for potential ASD management.

Main Methods:

  • Literature review of recent studies on mitochondrial dysfunction in ASD.
  • Analysis of evidence linking mtDNA abnormalities to ASD pathogenesis.
  • Summary of emerging therapeutic strategies targeting mitochondrial function.

Main Results:

  • Mitochondrial dysfunction is a significant factor in ASD development.
  • Abnormalities in mitochondrial DNA (mtDNA) are associated with ASD.
  • Several promising approaches to enhance mitochondrial function are emerging.

Conclusions:

  • Mitochondrial dysfunction and mtDNA alterations are critical in ASD pathogenesis.
  • Therapeutic strategies targeting mitochondrial health offer potential for managing ASD.
  • Further research into mitochondrial function in ASD is warranted for developing effective treatments.