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Far-Infrared Spectroscopy as a Probe for Polymorph Discrimination.

Kuthuru Suresh1, Jeffrey S Ashe1, Adam J Matzger2

  • 1Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109.

Journal of Pharmaceutical Sciences
|January 2, 2019
PubMed
Summary
This summary is machine-generated.

Far-infrared (IR) spectroscopy effectively differentiates pharmaceutical polymorphs by analyzing lattice vibrations. This technique offers superior discrimination compared to mid-IR spectroscopy, revealing crystal packing arrangements.

Keywords:
amorphouscrystal packingfar-IR spectroscopypharmaceuticalspolymorph

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Area of Science:

  • Analytical Chemistry
  • Materials Science
  • Pharmaceutical Science

Background:

  • Crystalline polymorph and amorphous form detection is crucial in pharmaceuticals.
  • Mid-infrared (IR) spectroscopy is commonly used but limited in differentiating polymorphs due to functional group vibrations.
  • Distinguishing polymorphs is essential for drug efficacy and safety.

Purpose of the Study:

  • To evaluate the value of far-infrared (IR) spectroscopy for pharmaceutical polymorph differentiation.
  • To compare the discriminating power of far-IR versus mid-IR spectroscopy.
  • To investigate the relationship between far-IR spectra and crystal packing arrangements.

Main Methods:

  • Preparation of 10 polymorphic pharmaceutical samples.
  • Acquisition and analysis of far-infrared (IR) spectra.
  • Comparison of spectral data with mid-infrared (IR) spectra.

Main Results:

  • Far-IR spectroscopy demonstrated high discriminating power for polymorph differentiation.
  • The far-IR region, sensitive to lattice vibrational modes, provided better discrimination than the mid-IR region.
  • Analysis of far-IR spectra allowed for the derivation of structural similarities and dissimilarities in polymorphic packing.

Conclusions:

  • Far-infrared (IR) spectroscopy is a valuable tool for distinguishing pharmaceutical polymorphs.
  • The technique offers enhanced discrimination by probing intermolecular forces and crystal lattice vibrations.
  • Far-IR spectroscopy provides insights into polymorphic packing arrangements, aiding in structural characterization.