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Updated: Jan 31, 2026

Intravital Microscopy Imaging of the Liver following Leishmania Infection: An Assessment of Hepatic Hemodynamics
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Evaluating CKD/ESRD patient with hepatitis C infection: How to interpret diagnostic testing and assess liver injury

Claudia Cottone1, Kalyan Ram Bhamidimarri2

  • 1Department of Internal Medicine, Chicago Medical School at Northwestern Medicine - McHenry Hospital, McHenry, Illinois.

Seminars in Dialysis
|January 2, 2019
PubMed

Insights

Chronic hepatitis C (CHC) is a significant cause of death, particularly in patients with chronic kidney disease (CKD) on hemodialysis (HD). Early detection and treatment of CHC are crucial for improving outcomes in this vulnerable population.

Area of Science:

  • Hepatology and Nephrology
  • Infectious Diseases

Background:

  • Chronic hepatitis C (CHC) is a leading cause of infection-related mortality, with higher prevalence in chronic kidney disease (CKD) and hemodialysis (HD) patients.
  • Many CHC patients are asymptomatic and undiagnosed, necessitating proactive screening and management.
  • Guidelines emphasize early detection and linkage to care for CHC patients, especially those with CKD/HD.

Purpose of the Study:

  • To review current methodologies for evaluating liver fibrosis in hepatitis C virus (HCV)-infected CKD/HD patients.
  • To provide an update on diagnostic tests and assessment tools for liver fibrosis in this specific patient group.
  • To highlight advancements in managing HCV in CKD and hemodialysis populations.

Main Methods:

  • Literature review of diagnostic tests for liver fibrosis.
  • Analysis of assessment tools for liver disease in CKD/HD patients.
  • Synthesis of recent therapeutic strategies for HCV in renal impairment.

Main Results:

  • Significant evolution in liver assessment tools, HCV testing, and therapies.
  • Improved management strategies for HCV in CKD and hemodialysis patients.
  • Paradigm shift in the treatment approach for HCV in renal patients.

Conclusions:

  • Early detection and timely treatment of CHC are vital for CKD/HD patients.
  • Advancements in diagnostics and therapeutics have transformed HCV management in this population.
  • Ongoing research and guideline updates are essential for optimal patient care.

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