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microRNA-27a and microRNA-146a SNP in cerebral malaria

Saw Thu Wah1,2, Hathairad Hananantachai3, Jintana Patarapotikul3

  • 1Department of Clinical Microscopy, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.

Molecular Genetics & Genomic Medicine
|January 2, 2019
PubMed
Abstract

Insights

Single-nucleotide polymorphisms (SNPs) in microRNAs do not appear to significantly influence susceptibility to cerebral malaria. This study found no major role for candidate microRNA SNPs in the development of cerebral malaria in Thai patients.

Area of Science:

  • Genetics
  • Immunology
  • Molecular Biology

Background:

  • Cerebral malaria is linked to altered microRNA expression in brain tissue.
  • MicroRNAs regulate gene expression post-transcriptionally, impacting biological processes.
  • Cerebral malaria pathology is primarily driven by immunological disorders.

Purpose of the Study:

  • To investigate the hypothesis that single-nucleotide polymorphisms (SNPs) in microRNAs affect susceptibility to cerebral malaria.
  • To examine microRNA SNPs potentially involved in cerebral malaria pathogenesis.
  • To assess the association between specific microRNA SNPs and cerebral malaria outcomes.

Main Methods:

  • Literature search on immunological mechanisms and microRNA SNP databases.
  • Genotyping assays (TaqMan) for three candidate microRNA SNPs (rs895819, rs57095329, rs2910164) in 110 cerebral malaria and 207 uncomplicated malaria cases.
  • Analysis of genotype, allele frequencies, and haplotypes.

Main Results:

  • No significant differences were found in genotype or allele frequencies for individual microRNA SNPs or microRNA-146a haplotypes between patient groups.
  • Hardy-Weinberg disequilibrium (heterozygous excess) was observed for rs57095329 in the cerebral malaria group, suggesting potential natural selection.
  • The investigated microRNA SNPs did not show a significant association with cerebral malaria development.

Conclusions:

  • Candidate microRNA SNPs investigated in this study do not play a major role in the development of cerebral malaria.
  • Further research may be needed to explore other genetic or immunological factors contributing to cerebral malaria susceptibility.
Keywords:
Thaicerebral malariamicroRNA SNPrs2910164rs57095329rs895819

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