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Updated: Jan 31, 2026
14:22
Activating Molecules, Ions, and Solid Particles with Acoustic Cavitation
Published on: April 11, 2014
15.6K
Characterization of cavitation-radiated acoustic power using diffraction correction.
Kyle T Rich1, Christy K Holland2, Marepalli B Rao3
1Department of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio 45221, USA.
The Journal of the Acoustical Society of America
|January 3, 2019
Summary
A new method estimates acoustic power from cavitation bubbles using a diffraction correction factor. This approach improves measurements for ultrasound-enhanced sonophoresis, correlating acoustic power with skin permeability.
Area of Science:
- Acoustics
- Biophysics
- Ultrasound Technology
Background:
- Accurate measurement of acoustic power from cavitation is crucial for understanding ultrasound applications.
- Passive Cavitation Detectors (PCDs) measure pressure but require corrections for accurate acoustic power estimation.
- Existing methods lack a universal approach for diverse cavitation bubble distributions.
Purpose of the Study:
- To develop a method for compensating absolute pressure measurements from a calibrated Passive Cavitation Detector (PCD).
- To estimate the average acoustic power radiated from a region of interest (ROI) encompassing cavitating bubbles.
- To enable precise comparison of cavitation levels across different therapeutic ultrasound configurations.
Main Methods:
- Derived a diffraction correction factor as an analytic expression for converting PCD-measured pressures to acoustic power.
- Accounted for position- and frequency-dependent PCD sensitivity in the correction factor.
- Validated the correction factor using simulations across various ROI dimensions and frequencies.
Main Results:
- The diffraction correction factor accurately estimates acoustic power without needing bubble distribution data.
- Applied the factor to *in vitro* ultrasound-enhanced sonophoresis experiments.
- Observed a strong correlation between acoustic power of subharmonic emissions and increased skin permeability at 0.41 and 2.0 MHz.
Conclusions:
- The developed method provides a universal approach for acoustic power estimation from cavitation.
- This technique facilitates reliable comparisons of therapeutic ultrasound efficacy.
- Acoustic power is a key determinant of ultrasound-induced skin permeability changes.
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