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Related Concept Videos

Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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What is Cancer?02:12

What is Cancer?

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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Related Experiment Video

Updated: Jan 31, 2026

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
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c-MYB and DMTF1 in Cancer.

Elizabeth A Fry1, Kazushi Inoue1

  • 1a The Department of Pathology , Wake Forest University School of Medicine , Winston-Salem , NC , USA.

Cancer Investigation
|January 3, 2019
PubMed
Summary

The oncogene c-Myb drives cancer, while Dmp1 acts as a tumor suppressor. Aberrant expression of these transcription factors impacts human cancers and their clinical outcomes.

Area of Science:

  • Molecular biology
  • Cancer research
  • Genetics

Background:

  • The c-Myb gene encodes a transcription factor crucial for cell regulation, frequently overexpressed in cancers like leukemia and breast cancer, indicating its oncogenic role.
  • Specific chromosomal translocations lead to aberrant c-MYB fusion proteins in various human leukemias and carcinomas.
  • Therapeutic strategies targeting c-Myb include antisense oligonucleotides and small molecule inhibitors disrupting its interactions.

Purpose of the Study:

  • To discuss the significance of aberrant expression of c-Myb and Dmp1 (Dmtf1) proteins in human cancers.
  • To explore the clinical implications of these transcription factors in cancer development and progression.

Main Methods:

  • Review of literature on c-Myb and Dmp1 (Dmtf1) gene function and expression in human cancers.
Keywords:
DMP1 (DMTF1)anti-sense oliodeoxynucleotidesbreast cancerc-MYBexpressionleukemiasmall moleculesolid tumorsuper enhancertherapy

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  • Analysis of the role of c-Myb in cell proliferation, differentiation, and apoptosis.
  • Investigation of Dmp1's interaction with cyclin D2, p53, and its role in the p53 pathway.

    • Main Results:

    • c-Myb is a proto-oncogene frequently overexpressed in human leukemias and solid tumors.
    • Dmp1 (Dmtf1) functions as a transcription factor, interacts with p53, and its deletion is linked to longer survival in cancer patients.
    • Aberrant expression patterns of both c-Myb and Dmp1 are significant in human cancers.

    Conclusions:

    • Both c-Myb and Dmp1 are critical transcription factors with significant roles in human oncogenesis.
    • Understanding their aberrant expression and interactions provides insights into cancer mechanisms and potential therapeutic targets.