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[Calcium and the liver].

M Claret1, J P Mauger

  • 1Unité de Recherche INSERM U. 274 Physiologie et Pharmacologie Cellulaire, Université Paris-Sud, Orsay, France.

Annales D'Endocrinologie
|January 1, 1988
PubMed
Summary
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Cellular calcium regulation is crucial for various functions, including glucose mobilization in liver cells. Hormones and bile acids influence intracellular calcium levels, impacting cell signaling pathways.

Area of Science:

  • Cell Biology
  • Biochemistry

Context:

  • Cytosolic free calcium ([Ca2+]i) is maintained at low levels, requiring active extrusion against electrochemical gradients.
  • Organelles like the endoplasmic reticulum and mitochondria concentrate cytosolic Ca2+.

Purpose:

  • To explore the role of calcium ions as amplifier signals in hormone and neurotransmitter-mediated glucose mobilization in liver cells.
  • To investigate the mechanisms by which hormones and bile acids alter intracellular calcium concentrations.

Summary:

  • Hormones and neurotransmitters increase [Ca2+]i by releasing calcium from the endoplasmic reticulum and stimulating influx, mediated by inositol lipid hydrolysis.
  • Bile acids also release calcium from the endoplasmic reticulum in liver cells, but through a pathway independent of hormone messengers.
  • Mobilization of cellular calcium and/or protons by these messengers is vital for diverse cellular functions.

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Impact:

  • Understanding calcium signaling is key to deciphering cellular responses to various stimuli.
  • This research highlights the distinct pathways through which hormones and bile acids modulate intracellular calcium.
  • The findings contribute to the broader understanding of cell signaling and its role in metabolic regulation.