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Updated: Jan 31, 2026

Mammalian Cell Encapsulation in Alginate Beads Using a Simple Stirred Vessel
Published on: June 29, 2017
Flexible heteroionic calcium-magnesium alginate beads for controlled drug release
Noelia M Sanchez-Ballester1, Ian Soulairol2, Bernard Bataille1
1Institut Charles Gerhardt UMR5253 Equipe MACS, UFR Science Pharmaceutique - Université Montpellier, Montpellier, France.
Abstract:
In the present work heteroionic calcium-magnesium alginate beads have been prepared by ionotropic gelation using different Ca:Mg ratios. This simple and straightforward approach allowed the obtention of CaMg-alginate beads presenting different mechanical performance depending on the Mg:Ca ratio. The dynamic swelling behavior of the beads was investigated. Increase in the quantity of Mg2+ incorporated in the beads increased the rate of swelling at pH 1.2 and pH 7.2. Finally, the release of ibuprofen was investigated. It was found that increasing the Mg2+ present in the beads raised the drug release rate.
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