Related Experiment Video
Updated: Jan 31, 2026

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
Published on: June 20, 2014
Characterization, bioactivity and pharmacokinetic study of a novel carbohydrate-peptide polymer: Glycol-split
Feng Sun1, Zhendong Wang1, Zhifang Yang1
1National Glycoengineering Research Center, Shandong University, Jinan, 250012, Shandong, PR China; Shandong Provincial Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, Jinan, 250012, Shandong, PR China.
Abstract:
Endostatin (ES) has attracted considerable attention for the treatment of anti-angiogenesis-related disorders. An 11-amino-acid peptide (ES2, IVRRADRAAVP) from the amino terminal of ES is of interest because it is the main active fragment of ES. However, both ES and ES2 have a poor stability and a short half-life, and other disadvantages need to be further resolved. Thus, we conjugated ES2 to glycol-split heparin derivatives (GSHPs) to yield the polymer-peptide conjugate, GSHP-ES2. This study showed that GSHP-ES2 exhibited increased stability, a wider pH activity range, better inhibition of endothelial cell proliferation, migration and tube formation in vitro, better anti-angiogenic activity and a longer half-life in vivo compared with ES2. These results also indicate that GSHP-ES2 has good potential for the treatment of angiogenesis-related diseases, either alone or in combination with other chemicals.
Related Concept Videos
Chemistry of Carbohydrates
Chemistry of Carbohydrates
What are Carbohydrates?
Polymers
Carbohydrate Digestion
Peptide Bonds

