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Related Concept Videos

Electron Carriers01:24

Electron Carriers

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Electron carriers can be thought of as electron shuttles. These compounds can easily accept electrons (i.e., be reduced) or lose them (i.e., be oxidized). They play an essential role in energy production because cellular respiration is contingent on the flow of electrons.
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Related Experiment Video

Updated: Jan 31, 2026

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Challenging the Current Recommendations for Carrier Testing in Children.

Grace E VanNoy1, Casie A Genetti1, Amy L McGuire2

  • 1Division of Genetics and Genomics and The Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, Massachusetts.

Pediatrics
|January 3, 2019
PubMed
Summary

Returning genetic carrier status information for children is debated due to potential harms versus benefits. The BabySeq Project explores implications of genomic sequencing in newborns, developing policies for returning carrier status results.

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Area of Science:

  • Genetics
  • Pediatrics
  • Bioethics

Background:

  • Current guidelines often discourage returning genetic carrier status results for children.
  • Concerns include lack of immediate benefit, potential harm, and protecting future autonomy.
  • Genomic sequencing in childhood now makes identifying carrier status more feasible.

Purpose of the Study:

  • To explore the implications of returning genetic carrier status information identified through genomic sequencing in newborns.
  • To develop policies and procedures for managing and returning this sensitive genetic data.
  • To review historical approaches to pediatric genetic testing and its associated ethical considerations.

Main Methods:

  • The BabySeq Project is investigating genomic sequencing in both healthy and sick newborns.
  • This commentary reviews existing literature and ethical frameworks regarding carrier testing in children.
  • The study examines the potential benefits, risks, and challenges associated with returning carrier status results.

Main Results:

  • Genomic sequencing in pediatric populations presents new opportunities for identifying genetic carrier status.
  • There is a need for careful consideration of ethical issues, parental consent, and potential psychological impact.
  • The BabySeq Project aims to establish best practices for handling and returning such genetic information.

Conclusions:

  • Returning genetic carrier status results from newborn genomic sequencing requires a nuanced approach.
  • Balancing potential benefits for family planning and reproductive choices against risks to the child is crucial.
  • Developing clear policies is essential for responsible implementation of genomic screening in pediatrics.