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Validating microscopic colitis (MC) in Swedish pathology registers.
Magnus Svensson1, David Bergman2, Ola Olén3,4
1a Department of Paediatrics , Örebro University Hospital , Örebro , Sweden.
Scandinavian Journal of Gastroenterology
|January 3, 2019
Summary
This study confirms that microscopic colitis (MC) diagnoses in Swedish pathology registers are highly accurate. The positive predictive value for MC was 95%, indicating reliable diagnostic criteria.
Area of Science:
- Gastroenterology
- Pathology
- Clinical Diagnostics
Background:
- Microscopic colitis (MC), including collagenous colitis (CC) and lymphocytic colitis (LC), is diagnosed based on histopathology.
- The accuracy of MC diagnoses recorded in pathology registers requires validation.
Purpose of the Study:
- To examine the validity of microscopic colitis diagnoses within Swedish pathology registers.
- To determine the positive predictive value (PPV) of MC diagnoses based on histopathology.
Main Methods:
- A review of patient charts from 215 individuals with MC histopathology codes across 15 pathology departments in Sweden.
- Collection of clinical symptoms and laboratory data from medical records for 211 individuals.
- Calculation of PPVs for MC, CC, and LC.
Main Results:
- A high PPV of 95% (95%CI =91-97%) was found for microscopic colitis overall.
- The PPV for collagenous colitis was 95% (95%CI =87-98%), and for lymphocytic colitis, it was 85% (95%CI =78-90%).
- Common symptoms included diarrhea (96%), weight loss (24%), and abdominal pain (13%); 26% had other autoimmune diseases.
Conclusions:
- Microscopic colitis diagnoses recorded in Swedish pathology registers demonstrate high validity.
- The histopathological criteria for MC are reliable for diagnostic purposes in this setting.
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