Association between Glutamine 27 Polymorphism of B2 Adrenergic Receptor and Bronchial Asthma in Children

Bronchial asthma is one of the most prevailed non-communicable diseases among Egyptian children. Genetic-environmental interaction can influence the nature of asthma and β2 agonists are the most commonly prescribed bronchodilators for relieving asthma symptoms. This study was conducted to investigate the possible relationship between Gln27/Glu polymorphism of ADRβ2 and bronchial asthma susceptibility, severity and responsiveness to Albuterol in Egyptian children. A case control study of one hundred Egyptian children, where all contributors were genotyped using allele-specific Polymerase chain reaction (AS-PCR). Cases were selected and classified according to GINA guidelines and spirometerically assessed to evaluate pulmonary functions. There were no statistically significant variances between patients and control regarding Gln27/Glu polymorphism. Gln27 genotype has positive association with both asthma severity and drug response. In conclusion; B2 adrenergic receptor polymorphism at codon 27 is not associated with asthma susceptibility; however, it can be a determinant factor for asthma severity and bronchodilating response to B2 agonists in Egyptian asthmatic children.