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Developing health literacy knowledge and skills through case-based learning.

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Related Experiment Video

Updated: Jan 31, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

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Migraine Headache Prophylaxis.

Hien Ha1, Annika Gonzalez1

  • 1Christus Santa Rosa Family Medicine Residency Program, San Antonio, TX, USA.

American Family Physician
|January 3, 2019
PubMed
Summary

Preventive therapies significantly reduce migraine frequency and severity. While many medications and complementary treatments exist, identifying triggers and utilizing non-pharmacologic options are key for effective migraine management.

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Migraines present substantial health and financial burdens.
  • Preventive therapy benefits many episodic migraine patients, yet underutilization is high.
  • Preventive treatments reduce migraine frequency, severity, and improve quality of life.

Purpose of the Study:

  • To review the evidence for various migraine preventive therapies.
  • To identify effective pharmacologic and non-pharmacologic migraine prevention strategies.

Main Methods:

  • Literature review of clinical evidence for migraine preventive medications.
  • Analysis of complementary and non-pharmacologic treatment efficacy.
  • Categorization of treatments based on evidence levels (effective, probably effective, limited evidence, ineffective).

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Related Experiment Videos

Last Updated: Jan 31, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
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Investigating Migraine-Like Behavior Using Light Aversion in Mice
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Main Results:

  • First-line effective medications include divalproex, topiramate, metoprolol, propranolol, and timolol.
  • Second-line options like amitriptyline and venlafaxine show probable effectiveness.
  • Complementary (Petasites, feverfew, magnesium, riboflavin) and non-pharmacologic therapies (relaxation, biofeedback, CBT) are also supported by good evidence.

Conclusions:

  • A range of pharmacologic, complementary, and non-pharmacologic options exist for migraine prevention.
  • Identifying and managing triggers is crucial.
  • Newer CGRP-targeting agents require further long-term study.