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Related Experiment Videos

Heredity and body fat.

C Bouchard1, L Pérusse

  • 1Physical Activity Sciences Laboratory, Laval University, Ste-Foy, Québec, Canada.

Annual Review of Nutrition
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Human obesity genetics involves additive effects and genotype-environment interactions. While some traits show low heritability, others like fat distribution have moderate genetic influence, with overfeeding highlighting interaction effects.

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Area of Science:

  • Human Genetics
  • Obesity Research
  • Metabolic Disorders

Background:

  • Obesity is a complex trait influenced by genetic and environmental factors.
  • Understanding the genetic basis of body fat and its distribution is crucial for public health.
  • Genetic disorders often present with obesity as a key clinical feature.

Purpose of the Study:

  • To review the genetics of human obesity, focusing on body fat and fat distribution.
  • To examine the role of heredity in obesity through genetic disorders.
  • To discuss additive genetic effects and genotype-environment interactions in body fat variation.

Main Methods:

  • Literature review of studies on human obesity genetics.
  • Analysis of genetic disorders with obesity as a clinical feature.

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  • Examination of various body fat indicators and their heritability.

    • Main Results:

    • Body Mass Index (BMI) and subcutaneous fat show low additive genetic effects (<10%).
    • Percentage body fat, fat mass, and fat distribution have heritability estimates around 25%.
    • Genotype-environment interaction significantly impacts body fat variation, especially with overfeeding.

    Conclusions:

    • Human obesity genetics is multifactorial, involving both additive genetic effects and genotype-environment interactions.
    • Heritability estimates for body fat traits vary, with some showing modest genetic influence.
    • Future research should explore genotype-environment interactions, particularly in response to dietary changes.