Optical Imaging Technology: A Useful Tool to Identify Remission in Cushing Disease After Surgery
Ali Afshari1, Margaret Keil2, Charalampos Lyssikatos2
1Section on Analytical and Functional Biophotonics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|January 3, 2019
Summary
Multi-spectral imaging (MSI) effectively quantifies facial changes in patients with Cushing disease (CD). This optical imaging method shows promise in predicting lasting remission after surgery for CD.
Area of Science:
- Endocrinology
- Medical Imaging
- Biophysics
Background:
- Endogenous Cushing syndrome (CS) presents diagnostic challenges.
- Facial plethora is a common sign of CS.
- Optical imaging offers a novel approach to quantify CS-related changes.
Purpose of the Study:
- To evaluate multi-spectral imaging (MSI) as a bio-optic marker for Cushing disease (CD) remission.
- To assess water and blood volume fractions as predictors of surgical treatment efficacy.
- To examine the utility of MSI in predicting lasting remission post-transsphenoidal surgery (TSS).
Main Methods:
- Multi-spectral imaging (MSI) was used to assess facial water and blood volume fractions in 49 patients with CD.
- Patients were imaged before and after transsphenoidal surgery (TSS).
- Follow-up imaging was conducted at 3-6 months and 12 months post-operatively.
Main Results:
- A significant decrease in blood volume fraction was observed post-surgery in 37 of 40 patients (p<0.001).
- All patients followed up to 12 months maintained remission and showed decreased blood volume fraction.
- MSI findings correlated with biochemical markers of remission.
Conclusions:
- MSI is a valuable tool for evaluating remission from CD in the post-operative period.
- This optical imaging technology can supplement biochemical testing for assessing treatment outcomes in CD.
- MSI provides objective bio-optic markers for predicting lasting remission after surgery for CS.
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