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An experiment is a planned activity carried out under controlled conditions. The purpose of an experiment is to investigate the relationship between two variables. When one variable causes change in another, we call the first variable the explanatory or independent variable. The affected variable is called the response or dependent variable. In a randomized experiment, the researcher manipulates values of the explanatory variable and measures the resulting changes in the response variable. The...
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Related Experiment Video

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Basophil Activation Test for Allergy Diagnosis
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[Perioperative allergy. A 3-year experience].

Rodrigo Collado-Chagoya1, Rubén Cruz-Pantoja, Javier Hernández-Romero

  • 1Secretaría de Salud, Hospital General de México, Servicio Alergia e Inmunología Clínica, Ciudad de México, México. rodnova87@hotmail.com.

Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
|January 3, 2019
PubMed
Summary

Perioperative hypersensitivity reactions are a significant health concern. Neuromuscular blocking agents, latex, and propofol were the most common triggers in a tertiary care hospital study.

Keywords:
AnaphylaxisHypnoticsLatexLocal anestheticsNeuromuscular blocking agentsPerioperative allergy

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Area of Science:

  • Anesthesiology
  • Immunology
  • Clinical Medicine

Background:

  • Perioperative hypersensitivity reactions are a global health issue.
  • Incidence is estimated at 1 in 100,000 procedures with a mortality rate of 0.1-9%.
  • Key risk factors include prior drug allergies, atopy, psychiatric conditions, and previous surgeries.

Purpose of the Study:

  • To determine the frequency of sensitization to perioperative allergens.
  • To identify the specific drugs involved in perioperative allergies.
  • To analyze data over a 3-year period in a tertiary care hospital setting.

Main Methods:

  • Retrospective, cross-sectional, descriptive study design.
  • Inclusion of patients diagnosed with perioperative allergy.
  • Confirmation of allergy through skin testing for drugs and latex.

Main Results:

  • Twenty-eight patients were diagnosed with perioperative allergy.
  • Neuromuscular blocking agents (46.42%), latex (28.52%), and propofol (14.28%) were primary triggers.
  • A history of previous surgeries (89.28%) was the most common risk factor; most reactions were mild (71.42%) and occurred postoperatively (60.71%).

Conclusions:

  • Anesthesiologists and surgeons should lead initial diagnosis and management.
  • Focus on prompt withdrawal of suspected causative agents is crucial.
  • Early recognition and intervention can mitigate adverse outcomes.