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Translocation t(1;7) revisited. Report of three further cases and review
P Willem1, M Pinto, R Bernstein
1Department of Human Genetics, School of Pathology, South African Institute for Medical Research, Johannesburg.
Cancer Genetics and Cytogenetics
|November 1, 1988
Abstract:
Three white patients, two with myelofibrosis and one with refractory anemia, presented with a t(1;7). The clinical and cytogenetic findings are discussed in the context of 45 cases already published. Rather than the specific association of t(1;7) with a particular hematologic disorder, a review of the literature strongly suggests correlation with therapeutic or environmental exposure to toxic substances. The proposed mechanisms to explain the origin of t(1;7) are briefly reviewed.
