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Integrin trafficking in cells and tissues

Paulina Moreno-Layseca1, Jaroslav Icha1, Hellyeh Hamidi1

  • 1Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.

Nature Cell Biology
|January 4, 2019
PubMed

Cell adhesion to the extracellular matrix is fundamental to metazoan multicellularity and is accomplished primarily through the integrin family of cell-surface receptors. Integrins are internalized and enter the endocytic-exocytic pathway before being recycled back to the plasma membrane. The trafficking of this extensive protein family is regulated in multiple context-dependent ways to modulate integrin function in the cell. Here, we discuss recent advances in understanding the mechanisms and cellular roles of integrin endocytic trafficking.

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