Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Integrins01:10

Integrins

5.4K
Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
5.4K
Activation of Integrins01:15

Activation of Integrins

5.1K
Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding...
5.1K
Plant Cells and Tissues02:01

Plant Cells and Tissues

65.7K
Plant tissues are collections of similar cells performing related functions. Different plant tissues will have their own specialized roles and can be combined with other tissues to form organs such as flowers, fruit, stem, and leaves. Two major types of plant tissue include meristematic and permanent tissue.
65.7K
Bone Cells and Tissue01:30

Bone Cells and Tissue

8.3K
Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
8.3K
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

3.2K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
3.2K
Nervous Tissue: Glial Cells01:31

Nervous Tissue: Glial Cells

6.9K
Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
6.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adhesion-derived condensates control component availability to regulate adhesion dynamics.

Nature communications·2026
Same author

Macrophages restrict tumor immune infiltration by controlling collagen topography.

Science immunology·2026
Same author

Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties.

Nature materials·2026
Same author

Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers.

The EMBO journal·2026
Same author

Regulation of cell dynamics by rapid integrin transport through the biosynthetic pathway.

The Journal of cell biology·2025
Same author

COVID-19 vaccine type controls stromal reprogramming in draining lymph nodes.

Science immunology·2025
Same journal

Author Correction: Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance.

Nature cell biology·2026
Same journal

An atlas of primate insular cortex reveals a signal-processing strategy in von Economo neurons.

Nature cell biology·2026
Same journal

Primate neurons with special signalling logic.

Nature cell biology·2026
Same journal

Cell surface liposome binding (CLiB) allows lipid-binding probe engineering via high-throughput screening.

Nature cell biology·2026
Same journal

Mapping the human female reproductive tract.

Nature cell biology·2026
Same journal

Learning from stem cell-based embryo models.

Nature cell biology·2026
See all related articles

Related Experiment Video

Updated: Jan 31, 2026

Analysis of SCAP N-glycosylation and Trafficking in Human Cells
11:27

Analysis of SCAP N-glycosylation and Trafficking in Human Cells

Published on: November 8, 2016

9.3K

Integrin trafficking in cells and tissues.

Paulina Moreno-Layseca1, Jaroslav Icha1, Hellyeh Hamidi1

  • 1Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.

Nature Cell Biology
|January 4, 2019
PubMed
Summary
This summary is machine-generated.

Cell adhesion relies on integrins, which are recycled via endocytic pathways. This study explores recent advances in understanding integrin endocytic trafficking mechanisms and cellular roles.

More Related Videos

Tracking Bispecific Antibody-Induced T Cell Trafficking Using Luciferase-Transduced Human T Cells
10:19

Tracking Bispecific Antibody-Induced T Cell Trafficking Using Luciferase-Transduced Human T Cells

Published on: May 12, 2023

1.6K
Tension Gauge Tether Probes for Quantifying Growth Factor Mediated Integrin Mechanics and Adhesion
09:56

Tension Gauge Tether Probes for Quantifying Growth Factor Mediated Integrin Mechanics and Adhesion

Published on: February 11, 2022

3.1K

Related Experiment Videos

Last Updated: Jan 31, 2026

Analysis of SCAP N-glycosylation and Trafficking in Human Cells
11:27

Analysis of SCAP N-glycosylation and Trafficking in Human Cells

Published on: November 8, 2016

9.3K
Tracking Bispecific Antibody-Induced T Cell Trafficking Using Luciferase-Transduced Human T Cells
10:19

Tracking Bispecific Antibody-Induced T Cell Trafficking Using Luciferase-Transduced Human T Cells

Published on: May 12, 2023

1.6K
Tension Gauge Tether Probes for Quantifying Growth Factor Mediated Integrin Mechanics and Adhesion
09:56

Tension Gauge Tether Probes for Quantifying Growth Factor Mediated Integrin Mechanics and Adhesion

Published on: February 11, 2022

3.1K

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Cell adhesion to the extracellular matrix is crucial for multicellular organisms.
  • Integrins are key cell-surface receptors mediating this adhesion.
  • Integrins undergo continuous internalization and recycling through the endocytic-exocytic pathway.

Purpose of the Study:

  • To review recent advancements in the understanding of integrin endocytic trafficking.
  • To elucidate the mechanisms and cellular functions associated with integrin trafficking.

Main Methods:

  • Literature review of recent studies on integrin trafficking.
  • Analysis of data on the regulation of integrin endocytosis and recycling.
  • Discussion of cellular models and experimental approaches used to study integrin trafficking.

Main Results:

  • Integrin trafficking is a highly regulated process.
  • Multiple context-dependent mechanisms control integrin internalization and recycling.
  • Endocytic trafficking significantly modulates integrin function within the cell.

Conclusions:

  • Understanding integrin endocytic trafficking is vital for comprehending cell adhesion and multicellularity.
  • Recent advances highlight the complexity and importance of regulated integrin recycling.
  • Further research into integrin trafficking mechanisms will uncover new insights into cellular processes.