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Published on: January 7, 2019
Bridging trees for posterior inference on ancestral recombination graphs
1Department of Mathematical Sciences, University of Bath, Claverton Down, Bath BA2 7AY, UK.
Abstract:
We present a new Markov chain Monte Carlo algorithm, implemented in the software Arbores, for inferring the history of a sample of DNA sequences. Our principal innovation is a bridging procedure, previously applied only for simple stochastic processes, in which the local computations within a bridge can proceed independently of the rest of the DNA sequence, facilitating large-scale parallelization.
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