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Serum proteins C and S levels as early biomarkers for kidney dysfunction in hemophilic patients

Maryam A Al-Ghamdi1, Etimad A Huwait1,2, Taha A Kumosani1,2,3

  • 1Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.

African Health Sciences
|January 4, 2019
PubMed

Insights

Serum proteins C and S are significantly decreased in hemophilia patients with kidney dysfunction. These proteins show potential as early biomarkers for detecting renal abnormalities in hemophilia.

Area of Science:

  • Hematology
  • Nephrology
  • Biochemistry

Background:

  • Hemophilia is a genetic bleeding disorder impacting blood coagulation.
  • Early detection of renal dysfunction in hemophilic patients is crucial.
  • Serum proteins C and S are investigated for their role in renal health.

Purpose of the Study:

  • To evaluate serum proteins C and S levels in hemophilic patients.
  • To correlate these protein levels with kidney function tests.
  • To assess their utility in early diagnosis of renal abnormalities.

Main Methods:

  • Study involved 80 male subjects across four groups: healthy controls, renal dysfunction, hemophilia, and hemophilia with renal disorder.
  • Serum urea, creatinine, sodium, potassium, protein C, and protein S levels were measured.
  • Urinary albumin and creatinine levels were also analyzed.

Main Results:

  • Protein C and S levels were significantly lower in hemophilic patients with renal dysfunction (P < 0.001).
  • Positive correlations were found between protein C/S levels and urinary albumin (P < 0.01).
  • Urinary albumin increased significantly (15-fold) in hemophilic patients with renal dysfunction.

Conclusions:

  • Serum proteins C and S demonstrate potential as predictive biomarkers for renal dysfunction in hemophilia.
  • Protein S showed a notable predictive value (ROC-AUC of 0.75).
  • These findings support the use of protein C and S for early renal abnormality detection.
Abstract

Keywords:
Hemophiliaprotein Cprotein Srenal dysfunction

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