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Expression of miR-520c in intestinal type gastric adenocarcinoma

Arash Azimzadeh-Isfanjani1, Reza Safaralizadeh1, Mohamadali Hosseinpour-Feizi1

  • 1Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.

Journal of Gastrointestinal Oncology
|January 4, 2019
PubMed
Abstract

Insights

This study found no significant difference in miR-520c expression in intestinal-type gastric adenocarcinoma (IGA) tissues. The findings do not support miR-520c

Area of Science:

  • Molecular Biology
  • Oncology
  • Biomarker Discovery

Background:

  • MicroRNAs regulate gene expression and are implicated in cancer development.
  • miR-520c has been previously suggested as an oncogenic microRNA.
  • Intestinal-type gastric adenocarcinoma (IGA) is a prevalent and aggressive cancer.

Purpose of the Study:

  • To investigate the expression of miR-520c in IGA tissues.
  • To determine the association between miR-520c expression and IGA clinicopathological features.

Main Methods:

  • Quantitative real-time PCR (qRT-PCR) was used to measure miR-520c levels.
  • Total RNA was extracted from 42 pairs of IGA and adjacent non-tumorous tissues.
  • Statistical analysis explored correlations with tumor grade, genus, and age.

Main Results:

  • No differential expression of miR-520c was observed in IGA tissues compared to controls.
  • miR-520c expression showed no significant correlation with clinicopathological parameters.

Conclusions:

  • This study is the first to report miR-520c expression specifically in IGA.
  • The findings do not corroborate the previously reported oncogenic role of miR-520c in IGA.
Keywords:
Biomarkergastric adenocarcinomamiR-520cmicroRNAoncogene

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