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Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Induced Pluripotent Stem Cells01:13

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
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Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
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Updated: Jan 31, 2026

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
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Stem Cell Tracing Through MR Molecular Imaging.

Rasoul Yahyapour1, Bagher Farhood2, Ghazale Graily3

  • 1School of Medicine, Jiroft University of Medical Sciences, Jiroft, 8813833435 Iran.

Tissue Engineering and Regenerative Medicine
|January 4, 2019
PubMed
Summary

Stem cell imaging using MRI is crucial for advancing stem cell therapy. This technique aids in selecting optimal cell types, doses, and delivery methods, improving treatment strategies for various diseases.

Keywords:
Cell therapyMRIMolecular imagingRegenerative medicineStem cell

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Area of Science:

  • Regenerative Medicine
  • Biomedical Imaging
  • Medical Technology

Background:

  • Stem cell therapy offers potential cures for incurable diseases like diabetes and cardiovascular disorders.
  • Effective stem cell transplantation requires precise strategies for cell selection, dosage, and delivery.
  • Unanswered questions regarding stem cell therapy necessitate advanced monitoring techniques.

Purpose of the Study:

  • To highlight the role of stem cell imaging in optimizing stem cell therapy strategies.
  • To explore the application of Magnetic Resonance Imaging (MRI) for non-invasive stem cell tracking.
  • To review various contrast agents and their use in stem cell imaging.

Main Methods:

  • Utilizing MRI as a non-invasive modality for stem cell imaging.
  • Investigating the use of contrast agents including superparamagnetic nanoparticles, fluorine, and gadolinium.
  • Examining reporter genes for stem cell tracking.
  • Assessing stem cell survival, differentiation, and contrast agent toxicity.

Main Results:

  • Various contrast agents and reporter genes have been employed for stem cell imaging.
  • Studies focus on evaluating stem cell survival, differentiation, and long-term fate post-transplantation.
  • In vivo and preliminary clinical studies show promising results for MRI-based stem cell imaging.

Conclusions:

  • Stem cell imaging, particularly with MRI, is vital for the successful clinical application of stem cell therapy.
  • MRI enables critical assessments of transplanted cell behavior and safety.
  • Continued research and clinical trials hold promise for widespread adoption of MRI for stem cell imaging.