Related Experiment Video
Updated: Jan 31, 2026
08:01
Analysis of Developing Tooth Germ Innervation Using Microfluidic Co-culture Devices
Published on: August 14, 2015
8.6K
Sympathetic Innervation of Stomach in Postnatal Development
A I Emanuilov1, P M Masliukov2, A D Nozdrachev3
1Yaroslavl State Medical University, Yaroslavl, 150000, Russia.
Summary
Sympathetic stomach innervation in rats shows neuron numbers stabilize after 10 days. Key enzymes like tyrosine hydroxylase are present, while calbindin-expressing neurons decrease with age.
Area of Science:
- Neuroscience
- Developmental Biology
- Gastroenterology
Background:
- The sympathetic nervous system regulates gastric functions.
- Understanding the development of stomach innervation is crucial for gastrointestinal health.
Purpose of the Study:
- To investigate the developmental trajectory of sympathetic innervation to the stomach in rats.
- To characterize the neurochemical profile of these innervating neurons throughout postnatal life.
Main Methods:
- Retrograde axon transport of Fast Blue was used to label sympathetic neurons innervating the stomach in rats.
- Immunohistochemistry was employed to detect specific neuronal markers, including tyrosine hydroxylase, neuropeptide Y, and calbindin.
Main Results:
- The number of sympathetic neurons innervating the stomach increased significantly during the first 10 days of postnatal life, then remained stable into senescence.
- All identified neurons contained tyrosine hydroxylase, a key enzyme in catecholamine synthesis.
- The proportion of neuropeptide Y-immunopositive neurons remained constant during development, whereas calbindin-immunoreactive neurons decreased within the first month of life.
Conclusions:
- Sympathetic stomach innervation in rats undergoes a rapid developmental phase in early life, followed by a period of stability.
- The neurochemical composition of these neurons evolves, with a notable decrease in calbindin expression during early development.
Related Concept Videos
01:25The Sympathetic Nervous System
103.5K
Overview
103.5K
01:21Stomach pH Regulation
7.2K
The human body carefully regulates the internal pH of different organs to maintain homeostasis. For example, while the blood plasma maintains a neutral pH of 7, the stomach lumen has an acidic pH of 1.5 - 3.5. The low pH of stomach lumen helps kill pathogens in the food and break down complex food molecules.
The acid-secreting gastric mucosal epithelial cells (parietal cells) lining the stomach lumen maintain the low pH in the lumen. Numerous ion transporters and channels on these parietal...
The acid-secreting gastric mucosal epithelial cells (parietal cells) lining the stomach lumen maintain the low pH in the lumen. Numerous ion transporters and channels on these parietal...
7.2K
01:26Stomach Histology
3.2K
The stomach comprises several layers that work together to facilitate digestion and protect the organ. The outermost layer is called the serosa, which provides support and protection to the stomach. The muscularis externa layer is responsible for the mechanical breakdown of food by contracting and moving the stomach. The submucosa layer, located beneath the muscularis externa, contains connective tissue, blood vessels, nerves, and glands that secrete mucus and other substances essential for...
3.2K
01:31Sympathetic Signaling
2.5K
Sympathetic signaling, a vital part of the autonomic nervous system, plays a crucial role in mobilizing the body's resources in response to stress or emergencies. It involves the transmission of nerve impulses from sympathetic preganglionic fibers to postganglionic fibers. This results in the release of specific neurotransmitters and activation of adrenergic receptors.
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
2.5K
01:20Sympathetic Pathways: Sympathetic Chain Ganglia
6.3K
The sympathetic chain ganglia, also known as the sympathetic trunk ganglia or paravertebral ganglia, are a series of ganglia located bilaterally on either side of the spinal column. These ganglia serve as relay stations for the sympathetic nervous system. Preganglionic neurons originating in the spinal cord project their axons to the sympathetic chain ganglia. Within the ganglia, these preganglionic fibers synapse with postganglionic neurons.The postganglionic neurons of the sympathetic trunk...
6.3K
01:16Gross Anatomy of the Stomach
3.1K
The human stomach is a vital part of the digestive system, performing multiple functions. It is located within the peritoneum, a serous membrane that lines the abdominal cavity. The stomach plays a central role in processing food substances and interacts with other digestive organs through coordinated digestive processes. The stomach has a characteristic J-shape and is divided into four main regions. The cardia is the first section where the esophagus connects to the stomach and is the entry...
3.1K