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Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
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Radioembolization with 90Y Resin Microspheres of Neuroendocrine Liver Metastases: International Multicenter Study on

A J A T Braat1, S C Kappadath2, H Ahmadzadehfar3

  • 1Department of Radiology and Nuclear Medicine, Imaging Division, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. a.j.a.t.braat@umcutrecht.nl.

Cardiovascular and Interventional Radiology
|January 4, 2019
PubMed
Abstract

Insights

Radioembolization is a safe and effective treatment for neuroendocrine neoplasm (NEN) liver metastases, achieving a 91% disease control rate and symptom alleviation in 79% of patients. This study confirms its efficacy in improving outcomes for NEN patients.

Area of Science:

  • Oncology
  • Radiology
  • Hepatology

Background:

  • Neuroendocrine neoplasms (NEN) with liver metastases often have limited treatment options.
  • Radioembolization shows promise, but high-quality evidence is scarce.

Purpose of the Study:

  • To evaluate the safety and efficacy of radioembolization for liver metastases in neuroendocrine neoplasms (NEN).
  • To address limitations in current literature regarding radioembolization in NEN patients.

Main Methods:

  • A large, international, multicentre retrospective study included 244 NEN patients with varying NEN grades.
  • Radiologic response (RECIST 1.1, mRECIST) and clinical outcomes were assessed at 3 and 6 months.
  • Toxicity, symptom response, and overall survival were secondary endpoints.

Main Results:

  • Objective response rates were 16% (RECIST 1.1) and 43% (mRECIST), with disease control rates of 91%.
  • Median overall survival varied by grade: 3.7 years (G1), 2.7 years (G2), and 0.7 years (G3).
  • Symptom improvement/resolution occurred in 79% of symptomatic patients; toxicity was generally low.

Conclusions:

  • Radioembolization is a safe and effective treatment for NEN liver metastases, demonstrating high disease control and symptom relief.
  • NEN grade/Ki67 index, tumor burden, and extrahepatic disease are significant prognostic factors for survival.
Keywords:
NENNETNeuroendocrine tumorRadioembolizationSIRT

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