Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

1.2K
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
1.2K
ER Retrieval Pathway01:45

ER Retrieval Pathway

4.8K
In the secretory pathway, vesicles transport proteins from one cellular compartment to another in forward transport to deliver the protein to its correct location. Occasionally, misfolded proteins and incorrect proteins escape their original compartments, and a retrieval pathway is used to return the escaped proteins to their original compartment.
The ER uses many checkpoints to prevent the entry of incorrectly folded or a resident protein as cargo onto a transport vesicle. These mechanisms...
4.8K
Association Areas of the Cortex01:21

Association Areas of the Cortex

9.3K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
9.3K
Motor and Sensory Areas of the Cortex01:14

Motor and Sensory Areas of the Cortex

7.4K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
7.4K
Somatosensory, Motor, and Association Cortex01:23

Somatosensory, Motor, and Association Cortex

2.7K
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
2.7K
Retrieval01:12

Retrieval

444
Retrieval is the process of getting information out of memory storage and back into conscious awareness. This ability is essential for daily tasks like brushing hair and teeth, driving to work, and performing job duties. Retrieval occurs in three ways: recall, recognition, and relearning.
Recall involves accessing information without cues, such as during an essay test, where individuals must retrieve facts and concepts from memory unaided. Another example is remembering the name of a colleague...
444

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A hierarchical porous hard carbon@Si@soft carbon material for advanced lithium-ion batteries.

Journal of colloid and interface science·2024
Same author

Supramolecular H-Aggregates of Squaraines with Enhanced Type I Photosensitization for Combined Photodynamic and Photothermal Therapy.

ACS nano·2024
Same author

Engineering PTS-based glucose metabolism for efficient biosynthesis of bacterial cellulose by Komagataeibacter xylinus.

Carbohydrate polymers·2024
Same author

Engineering Shewanella oneidensis-Carbon Felt Biohybrid Electrode Decorated with Bacterial Cellulose Aerogel-Electropolymerized Anthraquinone to Boost Energy and Chemicals Production.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2024
Same author

Phenotyping of FGF12A<sup>V52H</sup> mutation in mouse implies a complex FGF12 network.

Neurobiology of disease·2024
Same author

Research on the mechanism of threefold discrepancy in thermal conductivity between room temperature and phase transition temperature for 1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) crystals.

Physical chemistry chemical physics : PCCP·2024

Related Experiment Video

Updated: Jan 31, 2026

Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety
10:51

Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety

Published on: January 20, 2012

21.8K

The Glutamatergic Postrhinal Cortex-Ventrolateral Orbitofrontal Cortex Pathway Regulates Spatial Memory Retrieval.

Xinyang Qi1, Zhanhong Jeff Du2, Lin Zhu1

  • 1Department of Neurology, Affiliated ZhongDa Hospital, Institute of Neuropsychiatry, School of Medicine, Southeast University, Nanjing, 210009, China.

Neuroscience Bulletin
|January 4, 2019
PubMed
Summary

Researchers identified a specific brain pathway crucial for spatial memory retrieval. This pathway, involving the postrhinal cortex (POR) and ventrolateral orbitofrontal cortex (vlOFC), is vital for recalling spatial information and may offer insights into Alzheimer's disease (AD) and mild cognitive impairment (MCI).

Keywords:
Alzheimer’s diseaseMild cognitive impairmentPostrhinal cortexSpatial memoryVentrolateral orbitofrontal cortex

More Related Videos

Bovine Ovarian Cortex Tissue Culture
06:32

Bovine Ovarian Cortex Tissue Culture

Published on: January 14, 2021

5.4K
The Spatial Memory Game: Testing the Relationship Between Spatial Language, Object Knowledge, and Spatial Cognition
05:15

The Spatial Memory Game: Testing the Relationship Between Spatial Language, Object Knowledge, and Spatial Cognition

Published on: February 19, 2018

11.4K

Related Experiment Videos

Last Updated: Jan 31, 2026

Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety
10:51

Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety

Published on: January 20, 2012

21.8K
Bovine Ovarian Cortex Tissue Culture
06:32

Bovine Ovarian Cortex Tissue Culture

Published on: January 14, 2021

5.4K
The Spatial Memory Game: Testing the Relationship Between Spatial Language, Object Knowledge, and Spatial Cognition
05:15

The Spatial Memory Game: Testing the Relationship Between Spatial Language, Object Knowledge, and Spatial Cognition

Published on: February 19, 2018

11.4K

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Neurobiology

Background:

  • Spatial memory deficits are early indicators of Alzheimer's disease (AD) and mild cognitive impairment (MCI).
  • The uncinate fasciculus (UF) is implicated in aging and AD-related spatial memory decline, but its precise role is unclear.
  • The postrhinal cortex (POR) to ventrolateral orbitofrontal cortex (vlOFC) pathway in rodents mirrors UF functions, yet its role in spatial memory remains largely unexplored.

Purpose of the Study:

  • To elucidate the function of the POR-vlOFC pathway in spatial memory.
  • To investigate the specific contribution of this pathway to memory retrieval processes.

Main Methods:

  • Dissection of the POR-vlOFC pathway in a mouse model.
  • Characterization of the pathway's neurochemical properties (glutamatergic).
  • Assessment of the role of POR glutamatergic neurons in spatial memory retrieval.

Main Results:

  • The POR-vlOFC pathway was confirmed as a glutamatergic structure.
  • Glutamatergic neurons within the POR were found to regulate spatial memory retrieval.
  • The POR-vlOFC pathway was shown to specifically transmit spatial information essential for memory recall.

Conclusions:

  • The POR-vlOFC pathway plays a critical and specific role in the retrieval of spatial memories.
  • Understanding this pathway's function provides new insights into UF's role in memory and its dysfunction in conditions like MCI and AD.