Related Experiment Video For CD82 /KAI1
Updated: Jan 31, 2026

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
Published on: May 17, 2019
Exosomal protein CD82 as a diagnostic biomarker for precision medicine for breast cancer
Xiaodan Wang1, Weiliang Zhong2, Jingya Bu1
1Department of Clinical Laboratory, Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Abstract:
CD82, a member of the tetraspanin superfamily, has been proposed to exert its activity via tetra-transmembrane protein enriched microdomains (TEMs) in exosomes. The present study aimed to explore the potential of the exosome protein CD82 in diagnosing breast cancers of all stages and various histological subtypes in patients. The results strongly suggest that CD82 expression in breast cancer tissue was significantly lower than that in healthy and benign breast disease tissues. There was a significant negative correlation between CD82 expression in tissues and CD82 content in exosomes, which indicated that CD82 expression was redistributed from tissues to the blood with the development and metastasis of breast cancer.
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