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Retrograde and oscillatory shear increase across the menopause transition
Yasina B Somani1, David J Moore2, Danielle Jin-Kwang Kim3
1Department of Kinesiology, Penn State University, University Park, Pennsylvania.
Physiological Reports
|January 4, 2019
Summary
Menopause transition significantly alters blood flow patterns in major arteries, increasing risks for cardiovascular disease. Early postmenopausal women exhibit disturbed arterial shear rates, linked to hormonal changes and endothelial dysfunction.
Area of Science:
- Cardiovascular Physiology
- Reproductive Endocrinology
- Vascular Biology
Background:
- Endothelial function declines rapidly during menopause, increasing atherosclerosis risk.
- Disturbed conduit artery shear patterns are linked to endothelial dysfunction but not well-described across menopause.
Purpose of the Study:
- To describe and compare conduit artery shear patterns across the menopause transition.
- To investigate the relationship between reproductive hormones and arterial shear rates.
Main Methods:
- Doppler ultrasound measured blood velocity and diameter in brachial and femoral arteries of women in early perimenopause, late perimenopause, and early postmenopause.
- Serum hormone levels (estradiol, FSH, LH) were measured.
- Adjusted analyses accounted for age.
Main Results:
- Early postmenopausal women showed significantly higher brachial artery oscillatory shear compared to perimenopausal women.
- Retrograde shear in the brachial artery and both oscillatory and retrograde shear in the femoral artery were significantly greater in early postmenopausal women versus early perimenopausal women.
- Follicle-stimulating hormone (FSH) levels correlated significantly with retrograde and oscillatory shear in both brachial and femoral arteries.
Conclusions:
- Menopause transition and associated hormonal changes adversely affect conduit arterial shear patterns.
- Increased oscillatory and retrograde shear rates during early postmenopause may contribute to heightened cardiovascular risk.
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