Inflammatory biomarkers in benign paroxysmal positional vertigo: A Turkey case-control study

Area of Science:

• Neurology
• Otolaryngology
• Immunology

Background:

• Benign paroxysmal positional vertigo (BPPV) is a common cause of recurrent vertigo.
• Inflammation is a hypothesized etiological factor in BPPV.

Purpose of the Study:

• To evaluate inflammatory biomarker levels in BPPV patients.
• To compare these levels with healthy subjects.

Main Methods:

• Prospective case-control study with 114 BPPV patients and 83 healthy controls.
• Laboratory investigations included hemogram, biochemistry, vitamin levels, thyroid hormones, hsCRP, and ESR.
• Calculated neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte to HDL-cholesterol ratio (MHR).

Main Results:

• BPPV patients showed significantly lower Vitamin B12, hematocrit, creatinine, urea, fT4, lymphocyte, and bilirubin levels.
• Higher HDL, SGOT, and ESR values were found in BPPV patients.
• Significantly higher mean NLR, PLR, and mean platelet volume (MPV) were observed in BPPV patients compared to controls.

Conclusions:

• NLR, PLR, MPV, ESR, and bilirubin levels are potential biomarkers for BPPV prediction.
• These inexpensive and widely available parameters could be utilized in clinical practice.
• Further large-scale studies are needed to confirm these findings.