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Monocyte as an Emerging Tool for Targeted Drug Delivery: A Review

Fakhara Sabir1, Rai K Farooq2, Asim Ur Rehman1

  • 1Department of Pharmacy, Quaid-i-Azam University, Islamabad 45320, Pakistan.

Current Pharmaceutical Design
|January 4, 2019
PubMed

Insights

Monocytes, key immune cells, serve as effective drug delivery carriers. This review explores their potential in treating diseases like cancer and inflammation by targeting specific cell receptors.

Area of Science:

  • Immunology
  • Biomedical Engineering
  • Pharmacology

Background:

  • Monocytes are crucial phagocytic cells of the mononuclear phagocytic system.
  • They originate in bone marrow, circulate in blood, and differentiate into tissue macrophages.
  • Monocytes offer unique access to tissues, making them valuable drug delivery vehicles.

Purpose of the Study:

  • To review monocytes as a drug delivery system.
  • To discuss the design of lipid-based carriers for monocyte targeting.
  • To explore therapeutic applications in diseases like cancer, inflammation, and stroke.

Main Methods:

  • Review of literature on monocyte biology and drug delivery.
  • Analysis of passive and active targeting strategies for monocytes.
  • Examination of monocyte surface receptors (e.g., CD14, CD36) and targeting ligands.

Main Results:

  • Monocytes can be effectively targeted using various ligands and lipid-based systems.
  • Passive targeting leverages the enhanced permeation and retention effect.
  • Active targeting involves attaching specific ligands to carrier systems.

Conclusions:

  • Monocytes represent a promising platform for targeted drug delivery.
  • Their unique properties enable access to difficult-to-reach tissues.
  • Targeting monocytes holds potential for treating severe diseases, including cancer and inflammatory conditions.
Keywords:
Monocytesactive targetingligandslipid carrier systemmonocyte deliverypeptidesreceptors.

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