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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Disorders of Leukocytes01:27

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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
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Asthma I: Introduction01:28

Asthma I: Introduction

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Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
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Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

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Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
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Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

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Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
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Related Experiment Video

Updated: May 5, 2026

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
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A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

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Leukocyte count and bronchial hyperresponsiveness.

I Annesi1, F Kauffmann, M P Oryszczyn

  • 1INSERM U169, Villejuif, Paris, France.

The Journal of Allergy and Clinical Immunology
|December 1, 1988
PubMed
Summary
This summary is machine-generated.

Higher total leukocyte counts are linked to bronchial hyperresponsiveness in men. This association between leukocyte count and airway responsiveness remained significant even after accounting for smoking and other factors.

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Area of Science:

  • Pulmonology
  • Immunology
  • Epidemiology

Background:

  • Airway hyperresponsiveness (AHR) is a key feature of asthma and other respiratory conditions.
  • Leukocyte counts, reflecting systemic inflammation, have been explored for their potential role in AHR.
  • Understanding factors associated with AHR is crucial for improving respiratory health outcomes.

Purpose of the Study:

  • To investigate the association between total and differential blood leukocyte counts and bronchial methacholine responsiveness.
  • To determine if this association persists after adjusting for potential confounders like smoking, atopy, and infection.

Main Methods:

  • A population-based sample of 324 men was analyzed.
  • Bronchial methacholine challenge tests were used to assess airway responsiveness.
  • Statistical models (including logistic regression) were employed to analyze leukocyte counts and reactor status, adjusting for covariates.

Main Results:

  • Geometric mean total leukocyte counts were significantly higher in bronchial methacholine reactors compared to non-reactors (p = 0.003).
  • This significant association between higher leukocyte counts and reactor status persisted after adjusting for smoking habits.
  • The association remained significant even after controlling for atopy, common cold infection, and excluding individuals with pre-existing respiratory conditions.

Conclusions:

  • Elevated total leukocyte counts are significantly associated with bronchial hyperresponsiveness in men.
  • The findings suggest a potential link between systemic inflammation, indicated by leukocyte count, and airway responsiveness.
  • Further research is needed to explore the role of specific leukocyte types and cellular inflammation in bronchial hyperresponsiveness.