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MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method
Published on: October 7, 2025
227
MicroRNA replacement therapy in cancer.
Homa Mollaei1, Reza Safaralizadeh2, Zeinab Rostami3
1Department of Biology, Faculty of Sciences, University of Birjand, Birjand, Iran.
Journal of Cellular Physiology
|January 4, 2019
Summary
MicroRNAs (miRNAs) show promise as cancer therapeutics by regulating gene expression. This review explores their role in tumor development and therapeutic strategies, focusing on tumor suppressor miRNA mimics for cancer treatment.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- Cancer mortality rates remain high despite treatment advances.
- MicroRNAs (miRNAs) are small noncoding RNAs crucial for gene regulation.
- miRNAs influence cell physiology and disease, including cancer development.
Purpose of the Study:
- To review the role of miRNAs in tumor development.
- To present recent findings on miRNA-based cancer therapeutics.
- To focus on tumor suppressor miRNAs (mimics) and their delivery strategies.
Main Methods:
- Literature review of scientific publications.
- Analysis of miRNA functions in cancer.
- Evaluation of therapeutic strategies for miRNA delivery.
Main Results:
- miRNAs are key regulators of gene expression impacting cancer.
- Tumor suppressor miRNAs offer potential for targeted cancer therapy.
- Various strategies are being investigated for effective miRNA delivery.
Conclusions:
- miRNAs, particularly tumor suppressor mimics, represent a promising therapeutic avenue for cancer.
- Further research into safe and effective miRNA delivery systems is essential for clinical application.
