Related Experiment Video

Updated: Jan 31, 2026

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
08:30

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation

Published on: August 14, 2017

11.8K

Increased von Willebrand factor parameters in children with febrile seizures

Astrid Pechmann1, Sven Wellmann2, Benjamin Stoecklin2

  • 1Department of Neuropediatrics and Muscle Disorders, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Plos One
|January 4, 2019
PubMed

Insights

Children with febrile seizures (FS) show higher arginine vasopressin (AVP) levels, linked to increased von Willebrand factor (VWF) parameters. VWF collagen binding activity (VWF:CB) may help diagnose FS.

Area of Science:

  • Pediatrics
  • Hematology
  • Endocrinology

Background:

  • Von Willebrand factor (VWF) orchestrates blood coagulation and wound sealing.
  • Arginine vasopressin (AVP) release stimulates secretion of high molecular weight VWF multimers.
  • Elevated AVP levels, indicated by copeptin, were observed in children with febrile seizures (FS).

Purpose of the Study:

  • To investigate the biological function of increased AVP levels in children with FS.
  • To test the hypothesis that children with FS have elevated VWF parameters alongside higher AVP levels.

Main Methods:

  • Prospective, cross-sectional study of children aged 6 months to 5 years.
  • Inclusion criteria: fever or recent FS (within 4 hours).
  • Measured serum copeptin and VWF parameters (VWF:Ag, VWF:CB, VWF multimers) in FS, febrile control, and non-febrile control groups.

Main Results:

  • Significantly higher serum copeptin levels in children with FS compared to both control groups (p<0.001).
  • Significantly higher VWF:CB levels in children with FS compared to both control groups (p=0.048).
  • Multivariate analysis identified FS and copeptin as key determinants of VWF:CB.

Conclusions:

  • Increased AVP secretion in children with FS is associated with elevated plasma VWF parameters.
  • VWF:collagen binding activity (VWF:CB) may serve as an additional biomarker for diagnosing FS.
Abstract

More Related Videos

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy06:58

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy

Published on: July 12, 2021

5.7K
Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy09:18

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

Published on: January 12, 2019

10.9K

Related Concept Videos

Factors Influencing Drug Absorption: Anatomical Parameters01:23

Factors Influencing Drug Absorption: Anatomical Parameters

Drug absorption involves the movement of drugs from the point of administration into the systemic circulation. Initially, Gastrointestinal (GI) motility propels the drug through the digestive tract and into the stomach. However, the stomach's high acidity and limited surface area restrict its role in drug absorption for most drugs. The drug then moves from the stomach to the small intestine via gastric emptying, which can be slowed by various factors, including interactions with other...
631
Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
850
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
522
Increasing Function01:18

Increasing Function

An increasing function exhibits a rise in output values as input values increase. This behavior is depicted graphically as a curve or line that slopes upward from left to right. Such a function satisfies the condition that if x1 < x2, then f(x1) < f(x2), indicating that the function values grow with increasing inputs. This concept is fundamental in understanding growth trends across various domains, such as population dynamics, financial investments, or resource consumption.The...
391
Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
1.6K
Wave Parameters01:10

Wave Parameters

The simplest mechanical waves are associated with simple harmonic motion and repeat themselves for several cycles. These simple harmonic waves can be modeled using a combination of sine and cosine functions. Consider a simplified surface water wave that moves across the water's surface. Unlike complex ocean waves, in surface water waves, water moves vertically, oscillating up and down, whereas the disturbance of the wave moves horizontally through the medium. If a seagull is floating on the...
9.3K