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Related Concept Videos

Genomics02:02

Genomics

40.6K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
40.6K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

37.2K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
37.2K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

1.1K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.1K
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

9.1K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
9.1K
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

16.0K
The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
16.0K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

6.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.1K

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Updated: Jan 31, 2026

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Genomic medicine goes mainstream.

Joseph Conn

    Modern Healthcare
    |January 4, 2019
    PubMed
    Summary
    This summary is machine-generated.

    Genomic sequencing costs have decreased, enabling advanced patient care applications. However, widespread adoption in healthcare systems remains limited, with only a few leading institutions utilizing this powerful technology.

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    Area of Science:

    • Genomics
    • Healthcare Technology
    • Personalized Medicine

    Background:

    • The cost of genome sequencing has significantly decreased.
    • The clinical utility of genomic information for patient care has advanced considerably.
    • Limited integration of genomic data into routine healthcare practices.

    Purpose of the Study:

    • To highlight the gap between the potential of genomic sequencing and its current clinical implementation.
    • To identify the barriers and facilitators for adopting genomic information in healthcare systems.

    Main Methods:

    • Review of current literature on genomic sequencing costs and applications.
    • Analysis of case studies from pioneering healthcare systems integrating genomic data.
    • Assessment of technological and clinical workflow challenges.

    Main Results:

    • Genomic sequencing is more accessible and clinically relevant than ever before.
    • Pioneering healthcare systems are demonstrating successful integration models.
    • Significant challenges remain in widespread adoption, including data interpretation and infrastructure.

    Conclusions:

    • Despite advancements, the clinical application of genome sequencing is not yet widespread.
    • Further efforts are needed to overcome implementation barriers and promote broader healthcare system adoption.
    • The potential of genomic information to revolutionize patient care is largely untapped.