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Behavioral screening tools for identifying autism in macaques: existing and promising tests
Dongdong Qin1, Shihao Wu2, Yongchang Chen3
1Yunnan Key Laboratory of Primate Biomedicine Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China; Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan, 650500, China.
Brain Research Bulletin
|January 4, 2019
Summary
Developing behavioral screening tools for macaque models of autism is crucial. This review discusses current assays and promising new developments to advance autism research and potential human clinical trials.
Area of Science:
- Neuroscience
- Genetics
- Behavioral Science
Background:
- Autism Spectrum Disorder (ASD) is a neurodevelopmental condition marked by social communication deficits and repetitive behaviors.
- Genetic mutations are significant risk factors for ASD, driving preclinical research towards advanced animal models.
- Macaque models offer unique advantages over rodents due to their closer genetic relation to humans and complex social behaviors.
Purpose of the Study:
- To review existing behavioral phenotyping assays for macaque models of autism.
- To highlight promising new behavioral screening tools for enhanced translational utility.
- To guide the development of macaque models with high construct and face validity for autism research.
Main Methods:
- Comprehensive review of established behavioral tests used in macaque models for autism research.
- Identification and discussion of novel and emerging behavioral phenotyping assays.
- Analysis of the strengths and limitations of current and developing screening tools.
Main Results:
- Current behavioral phenotyping tools for macaque autism models are limited, restricting translational research.
- Emerging behavioral assays show promise for improving the validity and utility of macaque models.
- There is a need for enhanced tools to better capture the complexities of autism in macaque models.
Conclusions:
- Developing specialized behavioral screening tools is essential for advancing macaque models of autism.
- Future efforts should focus on improving construct and face validity, and fostering collaboration between rodent and macaque models.
- Enhanced macaque models are critical for translating preclinical findings into human clinical trials for autism.
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