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Kendall's Tau Test

Kendall's Tau Test

Kendall's tau test, also known as the Kendall rank coefficient test, is a nonparametric method for assessing association between two variables. This test is particularly useful for identifying significant correlations when the distributions of the sample and population are unknown. Developed in 1938 by the British statistician Sir Maurice George Kendall, the tau coefficient (denoted as τ) serves as a rank correlation coefficient, with values ranging from -1 to +1.
A τ value of +1 indicates...

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Related Experiment Video

Updated: Jan 31, 2026

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Published on: January 2, 2015

It's all about tau.

Cheril Tapia-Rojas¹, Fabian Cabezas-Opazo², Carol A Deaton³

¹Laboratory of Neurobiology of Aging, Centro de Biología Celular y Biomedicina (CEBICEM), Universidad San Sebastián, Santiago, Chile.

Progress in Neurobiology

|January 4, 2019

Summary

This summary is machine-generated.

This review explores the physiological roles of human tau protein beyond microtubule stabilization. Understanding tau

Keywords:

Axonal transport Dendrites Microtubules Posttranslational modifications Tau

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In Vitro Assay for Studying the Aggregation of Tau Protein and Drug Screening

In Vitro Assay for Studying the Aggregation of Tau Protein and Drug Screening

Published on: November 20, 2018

Area of Science:

Neuroscience
Cell Biology
Biochemistry

Background:

Tau protein is abundant in neurons, primarily known for stabilizing microtubules.
Emerging evidence suggests tau has broader functions, including axonal transport and synaptic regulation.
Understanding tau's normal physiological roles is crucial for neurodegenerative disease research, particularly Alzheimer's disease (AD).

Purpose of the Study:

To review the structure, organization, and physiological post-translational modifications of human tau.
To explore mechanisms regulating tau turnover under normal conditions.
To discuss newly identified functions of tau in a physiological context.

Main Methods:

Literature review focusing on human tau.
Synthesis of existing research on tau structure, modifications, and functions.
Analysis of mechanisms governing tau turnover and physiological roles.

Main Results:

Tau's functions extend beyond microtubule dynamics to include axonal transport, synaptic function, and neuronal signaling.
Various post-translational modifications of tau are associated with its physiological processes.
Mechanisms for tau turnover and novel physiological functions are being elucidated.

Conclusions:

A comprehensive understanding of tau's physiological functions and modifications is essential for deciphering its role in neurodegenerative conditions.
Further research into tau's normal cellular roles will provide a foundation for therapeutic strategies targeting tauopathies.
This review consolidates current knowledge on human tau's physiological aspects.