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Advanced drug delivery systems and artificial skin grafts for skin wound healing

Hye Sung Kim1, Xiaoyan Sun2, Jung-Hwan Lee3

  • 1Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA; Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Republic of Korea.

Advanced Drug Delivery Reviews
|January 4, 2019
PubMed

Insights

Advanced treatments for chronic wounds, including cell therapy and drug delivery systems, aim to improve healing outcomes. These strategies enhance drug effectiveness and restore skin function, addressing limitations in current clinical management.

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Dermatology

Background:

  • Chronic wounds, burns, and infections pose significant clinical challenges and healthcare costs.
  • Current management of non-healing wounds is often unsatisfactory.
  • There is a need for innovative strategies to improve wound repair quality.

Purpose of the Study:

  • To comprehensively review advanced treatment strategies for enhancing wound healing.
  • To explore novel therapeutic approaches for chronic and non-healing wounds.
  • To discuss the role of drug delivery systems and tissue engineering in wound care.

Main Methods:

  • Review of current literature on advanced wound healing modalities.
  • Analysis of strategies including growth factor and gene delivery.
  • Evaluation of cell therapy and cell-laden scaffolds for skin tissue replacement.

Main Results:

  • Drug delivery systems (nano, micro, macro) improve drug/gene bioavailability and pharmacokinetics.
  • Cell-laden scaffolds can restore skin barrier and regulatory functions.
  • These advanced methods offer potential for improved wound healing quality.

Conclusions:

  • Advanced therapeutic strategies show promise in overcoming limitations of current wound care.
  • Integration of drug delivery, gene therapy, and regenerative medicine can optimize healing.
  • Further research and clinical application of these methods are warranted.
Keywords:
ScaffoldSkin substituteWound healing

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