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Growth hormone therapy in children; research and practice - A review

Paulo Ferrez Collett-Solberg1, Alexander A L Jorge2, Margaret C S Boguszewski3

  • 1Pediatric Endocrinology, Departamento de Medicina Interna, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil.

Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society
|January 4, 2019
PubMed

Insights

Diagnosing and managing idiopathic short stature in children presents challenges. This review discusses recombinant human growth hormone therapy, genetic testing, and optimizing treatment for better growth outcomes.

Area of Science:

  • Pediatric Endocrinology
  • Genetics
  • Growth Disorders

Background:

  • Short stature is a common reason for pediatric endocrinology referrals, posing management challenges.
  • Idiopathic short stature diagnosis and the role of genetic investigations are areas of ongoing debate.
  • Optimizing recombinant human growth hormone (rhGH) therapy requires careful consideration of patient selection and dosing.

Purpose of the Study:

  • To review current controversies and complexities in the diagnosis and management of short stature in children.
  • To explore the utility of new genetic technologies in evaluating children with inadequate growth.
  • To discuss optimal strategies for recombinant human growth hormone (rhGH) therapy, including dosing and managing suboptimal responses.

Main Methods:

  • Literature review of current research and clinical guidelines on short stature management.
  • Analysis of the role of anthropometrical, biochemical, and genetic data in treatment decisions.
  • Discussion of diagnostic criteria and therapeutic approaches for idiopathic short stature.

Main Results:

  • The diagnosis of idiopathic short stature is complex, with emerging genetic technologies offering new insights.
  • Selection criteria for recombinant human growth hormone (rhGH) therapy and optimal dosing remain subjects of debate.
  • Defining and managing suboptimal responses to growth hormone therapy requires further investigation.

Conclusions:

  • Effective management of short stature necessitates a multidisciplinary approach, integrating clinical, genetic, and biochemical data.
  • Further research is needed to refine diagnostic tools and therapeutic strategies for children with short stature.
  • Optimizing growth hormone therapy is crucial for improving outcomes in children with growth deficiencies.

Keywords:
GeneticGrowthGrowth hormoneShort stature

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