[Experience in man with a purified rabies vaccine from huamn diploid cell (HDC) cultures (author's transl)]

A rabies HDC vaccine purified by density gradient centrifugation was used before and after exposure and the antigenic activity and tolerance investigated. Three injections on days 0, 7 and 21 induced neutralizing antibodies between 1:100 and 1: less than 1000 with 100% conversion rate, while one injection is sufficient for a booster. Vaccination after exposure is described; simultaneous passive immunization does not imply inhibition of the active immune response. Quantifiable local and general reactions seldom occur and serious neurological complications are not to be expected.