Stimulation of erythropoietin release by hypoxia and hypoxemia: similar but different
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Updated: Jan 31, 2026

Detection of Microregional Hypoxia in Mouse Cerebral Cortex by Two-photon Imaging of Endogenous NADH Fluorescence
Published on: February 21, 2012
Chang-Joon Lee1, David W Smith2, Bruce S Gardiner1
1Faculty of Engineering and Mathematical Sciences, The University of Western Australia, Perth, Australia; School of Engineering and Information Technology, Murdoch University, Perth, Australia.
Abstract:
Erythropoietin is released from the kidney in response to tissue hypoxia. Montero and Lundby found that increases in plasma erythropoietin induced by reducing arterial oxygen content in healthy humans were independent of arterial oxygen tension. Their observations accord with the established physiology of kidney oxygenation and can be predicted by a computational model of renal oxygen transport. However, model simulations indicate that the interpretation implicit in the title of their paper may be an oversimplification.
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