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Updated: Jan 31, 2026

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
Published on: December 1, 2016
Quaternized chitosan-stabilized copper sulfide nanoparticles for cancer therapy
Xiujie Huang1, Changliang Xu2, Yichen Li1
1State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, 381 Wushan Road, Guangzhou 510640, PR China.
Abstract:
In this study, we report a smart and green strategy to synthesize copper sulfide nanoparticles (CuS-NPs) for clinically translatable cancer treatment. For the first time, the preparation of CuS-NPs was developed by taking advantage of the copper-amine complex as the copper source and sodium sulfide as the sulfide source, in which the quaternized chitosan (QCS) was used as a biotemplate and stabilizing agent. The obtained QCS/CuS-NPs composites (CuS@QCS-NPs) were spherical and stable with an average diameter of 5.6 nm, and showed strong NIR absorbance for photothermal conversion. Moreover, in vitro and in vivo cancer theranostic capability of CuS@QCS-NPs without any biomodification was evaluated. The result reveals that after intratumoral (i.t.) injection of CuS@QCS-NPs with NIR laser irradiation (808 nm, 1.5 W/cm2, 5 min), the 4T1 mammary tumor growth could be effectively suppressed comparing with the other control groups, and there was no obvious lethal toxicity to liver function, kidney function, and vital organs. Such QCS-stabilized CuS-NPs may provide an alternative for clinical application of CuS-based photothermal therapy.
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